Chemo Causes Cancer
Tumors Grow Faster After Chemo and Why
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The news comes after it was previously ousted by similarly-breaking research that expensive cancer drugs not only fail to treat tumors but make them far worse. The cancer drugs were found to cause tumors to ‘metastasize’ and grow massively in size after consumption. As a result, the drugs killed the patients more quickly.
WNT16B, acting in a cell-nonautonomous manner, promotes the survival of cancer cells after cytotoxic therapy.
Consistent with previous studies, transcripts encoding matrix metalloproteinases such as MMP1, chemokines such as CXCL3, and peptide growth factors such as amphiregulin were substantially elevated in PSC27 fibroblasts after genotoxic damage19,20.
Chemo Causes Cancer
Notably, the expression of WNT16B increased between eightfold and 64-fold as a result of these treatments (P < 0.005)
In other words, chemotherapy causes cancer.
Treatment-induced damage to the tumor microenvironment promotes prostate cancer therapy resistance through WNT16B.
WNT16B protein was substantially and significantly increased after chemotherapy in the periglandular stroma, which included fibroblasts and smooth muscle cells (P < 0.01)
We confirmed these findings in breast and ovarian carcinomas, two other malignancies commonly treated with cytotoxic chemotherapy.
In patients with prostate cancer treated with neoadjuvant chemotherapy, higher WNT16B immunoreactivity in prostate stroma after treatment was associated with a significantly greater likelihood of cancer recurrence.
Cancer Drugs Lead to Metasitized Tumors
“Whatever manipulations we’re doing to tumors can inadvertently do something to increase the tumor numbers to become more metastatic, which is what kills patients at the end of the day,” – Dr. Raghu Kalluri.
Pericytes are cells present at intervals along the walls of capillaries (and post-capillary venules). In the CNS, they are essential for blood vessel formation, maintenance of the blood-brain barrier, regulation of immune cell entry to the central nervous system (CNS) and control of brain blood flow.1
Research on cancer drugs was completed at the Beth Israel Deaconess Medical Center in Boston, which shows they were ineffective and highly dangerous. The studies show that these cancer drugs may initially reduce tumor size but later cause tumors to metastasize aggressively. The drugs cause patients to develop life-threatening tumors that frequently kill patients more quickly. So why are we still using these drugs?
Mice in the studies had tumors that were treated with either imatinib or sunitinib. They found that the mouse model suggested that loss of pericytes leads to enhanced tumor hypoxia and metastasis. Please read the complete study to see the details.
The preliminary clinical studies with tissue samples from patients with invasive ductal carcinoma suggested that low numbers of vessel-associated pericytes significantly correlated with poor prognosis.
FROM THE STUDY: Using genetic mouse models or pharmacological inhibitors, pericyte depletion suppressed tumor growth but enhanced metastasis. Pericyte depletion was further associated with increased hypoxia, epithelial-to-mesenchymal transition (EMT), and Met receptor activation. Silencing of Twist or use of a Met inhibitor suppressed hypoxia and EMT/Met-driven metastasis. In addition, poor pericyte coverage coupled with high Met expression in cancer cells speculates the worst prognosis for patients with invasive breast cancer. Collectively, our study suggests that pericytes within the primary tumor microenvironment likely serve as important gatekeepers against cancer progression and metastasis.